BINDAZYMETM Human Anti-Gliadin EIA Kit For in-vitro diagnostic use Product code: IgG: MK135 IgA: MK136 IgG or IgA: MK137

Coeliac disease is an inflammatory disease of the small intestine caused by ingestion of wheat gluten or related proteins from rye or barley. In the small intestine, ingested gluten is broken down into gliadin peptides which are deamidated by the enzyme tissue transglutaminase (tTg) resulting in the substitution of glutamine amino acid residues with glutamic acid. These modified gliadin peptides produced by this deamidation reaction are crucial to the toxic mechanism of coeliac disease and enhance the immunogenicity of gliadin, provoking an immune response. In coeliac disease, presentation of deamidated peptides to cells of the immune system results in the production of IgA and IgG antibodies against gliadin and other auto-antigens resulting in a local intense inflammatory reaction leading to loss of villi and a dramatic reduction in the capacity to absorb nutrients.